The Blacks Stars’ World Cup qualifying campaign suffered a severe blow after losing 2-0 to Egypt in Alexandria on Sunday in their Group E contest.
A goal in each half from Mohammed Salah and Abdella El Said leaves Ghana five points off the Pharaohs.
In-form Mohammed Salah converted a spot kick two minutes away from the half time whistle to put the host in front.
Left back Harrison Afful tripped Hassan Trezeguet inside the box and the referee pointed to the spot for a penalty.
With just four minutes to end proceedings Abdalla Saied added the second when the Egyptians mounted a rare attack and he shot from close range to beat goalkeeper Brimah.
The result leaves Ghana in third place on the table with one point; five behind leaders Egypt and three behind second place Uganda who beat Congo 1-0 at home on Saturday.
1. Egypt 6pts
2. Uganda 4pts
3. Ghana 1pt
4. Congo 0pt
Source: Ghana/Starrfmonline.com/103.5FM/Tony Bebli