Ghana coach Kwesi Appiah has named youngsters Kwabena Owusu and Samuel Owusu in his starting line up to face Guinea Bissau on Tuesday.
In the absence of injured Christian Atsu, talented Serbia-based youngster Samuel Owusu will start from the right side of midfield with his fellow youngster Kwabena Owusu to partner Jordan Ayew in attack.
Meanwhile, Richard Ofori keeps his place in the post with John Boye returning from suspension to be partnered by Genk defender Aidoo who makes his first tournament appearance.
Andre Ayew will start from the left side of midfield as coach Appiah packs his squad with players capable of fighting to secure the needed result for the Black Stars.
Ghana were one of the favourites to win the Africa Cup of Nations, having lifted the title on four previous occasions, but they have gotten off to a slow start this time.
The Black Stars will face Guinea-Bissau tonight off the back of two draws against Benin and Cameroon.
Ghana might face a spirited Guinea side in Egypt, as the African Wild Dogs can only advance to the knockout stages if they win and other results go their way.
However, manager James Appiah has one of the strongest squads in the competition to choose from, including Thomas Partey, who is a transfer target for both Manchester United and Arsenal.
Richard Ofori; Andy Yiadom, Baba Rahman, John Boye, Joseph Aidoo, Mubarak Wakaso, Thomas Partey; Samuel Owusu, Kwabena Owusu, Jordan Ayew, Andre Ayew.