Coach Avram Grant has named Daniel Amartey and Thomas Partey in his starting line up to face Uganda in their Group D opener on Tuesday at the Stade Port Gentil.
The Atletico Madrid rising star got the nod ahead of Afriyie Acquah who has been struggling for game time at Italian outfit Torino.
Partey will partner Mubarak Wakaso in the middle of the park and will be supported on the flanks by Christian Atsu and Andre Ayew.
Captain Asamoah Gyan will lead the attack for the Black Stars this afternoon with Jordan Ayew playing just behind him.
The game is expected to kick off at 4pm GMT at the Stade de Port Gentil.
Ghana XI vs. Uganda:
Razak Braimah
Harrison Afful
Baba Rahman
John Boye
Daniel Amartey
Mubarak Wakaso
Thomas Partey
Christian Atsu
Asamoah Gyan
Jordan Ayew
Andre Ayew